INVITO AL MACC10

Posted on 30 agosto 2017

MACC_10 Programme Draft GEC paper

CONGRESSO ORGANIZZATO A CUNEO dallo STAFF di Oncologia di Cuneo (MArco Merlano) e il centro Centre Antoine-Lacassagne (Gerard Milanò)

Correlation of TP53 and MDM2 genotypes and clinical outcome in platinum-treated head and neck cancer patients with more than 10 years’ follow-up.

Posted on 8 marzo 2016

Vivenza D, Monteverde M, Lattanzio L, Tonissi F, Astesana V, Denaro N, Comino A, Russi E, Lo Nigro C, Merlano M. Int J Biol Markers. 2016 Feb 17:0. doi: 10.5301/jbm.5000192. Abstract PURPOSE: Adequate biomarkers are still required to optimize therapy in patients with locally advanced head and neck squamous carcinomas (HNSCC) treated with chemoradiotherapy (CRT). […]

Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients.

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Lo Nigro C, Ricci V, Vivenza D, Monteverde M, Strola G, Lucio F, Tonissi F, Miraglio E, Granetto C, Fortunato M, Merlano MC. World J Gastrointest Oncol. 2016 Feb 15;8(2):222-30. doi: 10.4251/wjgo.v8.i2.222. Abstract AIM: To investigate the prognostic role of invariant natural killer T (iNKT) cells and antibody-dependent cell-mediated cytotoxicity (ADCC) in wild type KRAS […]

Combination of mTOR and EGFR targeting in an orthotopic xenograft model of head and neck cancer.

Posted on 30 dicembre 2015

Bozec A, Ebran N, Radosevic-Robin N, Sudaka A, Monteverde M, Toussan N, Etienne-Grimaldi MC, Nigro CL, Merlano M, Penault-Llorca F, Milano G. Laryngoscope. 2015 Nov 24. doi: 10.1002/lary.25754. [Epub ahead of print] Abstract OBJECTIVES/HYPOTHESIS: Recent preclinical and clinical studies on head and neck squamous cell carcinoma (HNSCC) revealed synergistic effects when combining anti-EGFR agents with […]

p16 cutoff in head and neck squamous cell carcinoma: correlation between tumor and patient characteristics and outcome.

Posted on 4 novembre 2015

Merlano MC, Denaro N, Vivenza D, Monteverde M, Russi E, Lerda W, Comino A, Lo Nigro C. Int J Biol Markers. 2015 Oct 20:0. doi: 10.5301/jbm.5000175. [Epub ahead of print] Abstract BACKGROUND: p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma […]

Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer

Posted on 18 settembre 2015

Br J Cancer. 2015 Sep 15;113(6):970-8. doi: 10.1038/bjc.2015.302. Epub 2015 Sep 1. O’Leary K, Shia A, Cavicchioli F, Haley V, Comino A, Merlano M, Mauri F, Walter K, Lackner M, Wischnewsky MB, Crook T, Lo Nigro C, Schmid P. Abstract BACKGROUND: The transforming growth factor-beta (TGF- β) pathway has been implicated in proliferation, migration and […]

MGMT promoter methylation and glioblastoma: a comparison of analytical methods and of tumor specimens

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Int J Biol Markers. 2015 May 26;30(2):e208-16. doi: 10.5301/jbm.5000126. Lattanzio L, Borgognone M, Mocellini C, Giordano F, Favata E, Fasano G, Vivenza D, Monteverde M, Tonissi F, Ghiglia A, Fillini C, Bernucci C, Merlano M, Lo Nigro C. Abstract It is already well known that hypermethylation of the O6-methylguanine DNA methyltransferase (MGMT) gene promoter is […]

Non coding RNAs in head and neck squamous cell carcinoma (HNSCC): a clinical perspective.

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Anticancer Res. 2014 Dec;34(12):6887-96. Denaro N, Merlano MC, Russi EG, Lo Nigro C. Abstract BACKGROUND: Head and neck squamous cell carcinoma is a common cause of cancer death. Despite decades of clinical studies exploring new treatments and considerable advance in multimodality treatment, satisfactory curative rates have not yet been reached. In the last few decades […]

Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines.

Posted on 23 luglio 2015

Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines. Lattanzio L, Tonissi F, Monteverde M, Vivenza D, Russi E, Milano G, Merlano M, Lo Nigro C. Invest New Drugs. 2015 Apr;33(2):310-20. doi: 10.1007/s10637-015-0210-1. Abstract Introduction In complement to anti-EGFR therapy, the targeting of PI3K/AKT/mTOR signaling pathway is […]

The relevance of ADCC for EGFR targeting: A review of the literature and a clinically-applicable method of assessment in patients.

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The relevance of ADCC for EGFR targeting: A review of the literature and a clinically-applicable method of assessment in patients. Monteverde M, Milano G, Strola G, Maffi M, Lattanzio L, Vivenza D, Tonissi F, Merlano M, Lo Nigro C. Crit Rev Oncol Hematol. 2015 Aug;95(2):179-90. doi: 10.1016/j.critrevonc.2015.02.014. Abstract BACKGROUND: Advances in the understanding of tumor […]